ChloroquineV1, Main, Exploration, bibRecord, 003506

The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant

Identifieur interne : 003506 ( Main/Exploration ); précédent : 003505; suivant : 003507

The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant

Auteurs : M. F. Heath [Royaume-Uni] ; W. Jacobson [Royaume-Uni]

Source :

Lung [ 0341-2040 ] ; 1985-12-01.

RBID : ISTEX:8856E45A58B2FB10200D31DA90850F95F7F06705

English descriptors

KwdEn :
- Ambroxol, Lysosomes, Phospholipases, Pulmonary surfactant.
Teeft :
- Alveolar macrophages, Ambroxol, Chloroquine, Control activities, Heath, Imipramine, Jacobson, Lung surfactant, Lysosomal, Lysosomal fraction, Lysosomal phospholipase, Lysosomal phospholipases, Lysosome, Macrophage, Phosphatidylcholine, Phospholipase, Phospholipases, Phospholipid, Phospholipidosis, Pulmonary surfactant, Rabbit lung parenchyma, Surfactant.

Abstract

Abstract: Ambroxol inhibits activity against phosphatidylcholine of phospholipase A from the lysosomes of rabbit lung, and in lysates of alveolar macrophages. The inhibition is of the same potency as that of imipramine and chloroquine. The latter are 2 of the many drugs with similar structural features, but very different pharmacologic actions, that can cause phospholipidosis in vivo as a result of the inhibition of lysosomal phospholipases. Since ambroxol shares these structural features, and inhibits the phospholipase A in vitro, we propose that the ability of ambroxol to elevate levels of pulmonary surfactant arises, at least in part, from this inhibitory property.

Url:

https://api.istex.fr/ark:/67375/1BB-QQLQK2S0-K/fulltext.pdf

DOI: 10.1007/BF02713834

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000531
to stream Istex, to step Curation: 000531
to stream Istex, to step Checkpoint: 002265
to stream Main, to step Merge: 003580
to stream Main, to step Curation: 003506

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant</title>
<author><name sortKey="Heath, M F" sort="Heath, M F" uniqKey="Heath M" first="M. F." last="Heath">M. F. Heath</name>
</author>
<author><name sortKey="Jacobson, W" sort="Jacobson, W" uniqKey="Jacobson W" first="W." last="Jacobson">W. Jacobson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:8856E45A58B2FB10200D31DA90850F95F7F06705</idno>
<date when="1985" year="1985">1985</date>
<idno type="doi">10.1007/BF02713834</idno>
<idno type="url">https://api.istex.fr/ark:/67375/1BB-QQLQK2S0-K/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000531</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000531</idno>
<idno type="wicri:Area/Istex/Curation">000531</idno>
<idno type="wicri:Area/Istex/Checkpoint">002265</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002265</idno>
<idno type="wicri:doubleKey">0341-2040:1985:Heath M:the:inhibition:of</idno>
<idno type="wicri:Area/Main/Merge">003580</idno>
<idno type="wicri:Area/Main/Curation">003506</idno>
<idno type="wicri:Area/Main/Exploration">003506</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant</title>
<author><name sortKey="Heath, M F" sort="Heath, M F" uniqKey="Heath M" first="M. F." last="Heath">M. F. Heath</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, CB3 OES, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Paediatrics, University of Cambridge Clinical School, Addenbrooke’s Hospital, Hills Road, CB2 2QQ, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jacobson, W" sort="Jacobson, W" uniqKey="Jacobson W" first="W." last="Jacobson">W. Jacobson</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, CB3 OES, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Paediatrics, University of Cambridge Clinical School, Addenbrooke’s Hospital, Hills Road, CB2 2QQ, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Lung</title>
<title level="j" type="sub">An International Journal on Lungs, Airways and Breathing</title>
<title level="j" type="abbrev">Lung</title>
<idno type="ISSN">0341-2040</idno>
<idno type="eISSN">1432-1750</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="1985-12-01">1985-12-01</date>
<biblScope unit="volume">163</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="337">337</biblScope>
<biblScope unit="page" to="344">344</biblScope>
</imprint>
<idno type="ISSN">0341-2040</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0341-2040</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ambroxol</term>
<term>Lysosomes</term>
<term>Phospholipases</term>
<term>Pulmonary surfactant</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Alveolar macrophages</term>
<term>Ambroxol</term>
<term>Chloroquine</term>
<term>Control activities</term>
<term>Heath</term>
<term>Imipramine</term>
<term>Jacobson</term>
<term>Lung surfactant</term>
<term>Lysosomal</term>
<term>Lysosomal fraction</term>
<term>Lysosomal phospholipase</term>
<term>Lysosomal phospholipases</term>
<term>Lysosome</term>
<term>Macrophage</term>
<term>Phosphatidylcholine</term>
<term>Phospholipase</term>
<term>Phospholipases</term>
<term>Phospholipid</term>
<term>Phospholipidosis</term>
<term>Pulmonary surfactant</term>
<term>Rabbit lung parenchyma</term>
<term>Surfactant</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Ambroxol inhibits activity against phosphatidylcholine of phospholipase A from the lysosomes of rabbit lung, and in lysates of alveolar macrophages. The inhibition is of the same potency as that of imipramine and chloroquine. The latter are 2 of the many drugs with similar structural features, but very different pharmacologic actions, that can cause phospholipidosis in vivo as a result of the inhibition of lysosomal phospholipases. Since ambroxol shares these structural features, and inhibits the phospholipase A in vitro, we propose that the ability of ambroxol to elevate levels of pulmonary surfactant arises, at least in part, from this inhibitory property.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
</region>
<settlement><li>Cambridge</li>
</settlement>
<orgName><li>Université de Cambridge</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Heath, M F" sort="Heath, M F" uniqKey="Heath M" first="M. F." last="Heath">M. F. Heath</name>
</region>
<name sortKey="Heath, M F" sort="Heath, M F" uniqKey="Heath M" first="M. F." last="Heath">M. F. Heath</name>
<name sortKey="Jacobson, W" sort="Jacobson, W" uniqKey="Jacobson W" first="W." last="Jacobson">W. Jacobson</name>
<name sortKey="Jacobson, W" sort="Jacobson, W" uniqKey="Jacobson W" first="W." last="Jacobson">W. Jacobson</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003506 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003506 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:8856E45A58B2FB10200D31DA90850F95F7F06705
   |texte=   The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant

The inhibition of lysosomal phospholipase A from rabbit lung by ambroxol and its consequences for pulmonary surfactant

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri